A 6-month, double-blind, placebo-controlled,
randomized trial to evaluate the effect of Eurycoma
longifolia (Tongkat Ali) and concurrent training on
erectile function and testosterone levels in androgen
deficiency of aging males (ADAM)

Alice Erwig Leitão, Melissa Carvalho de Souza Vieira, Andreia Pelegrini, Edson Luizda Silva, Adriana Coutinho de Azevedo Guimarães

Background

Androgen deficiency of aging males (ADAM) largely manifests as sexual symptoms. Erectile dysfunction is one of the most common symptoms of ADAM.

Aim

To ascertain the effect of concurrent training and supplementation with Eurycoma longifolia on erectile function and testosterone levels in men with ADAM, and the association of erectile function with levels of total testosterone.

Methods

6-month, randomized, double-blind, placebo-controlled four-arm clinical. 45 men (47.38 ± 5.03 years) were randomized into 4 groups (G1: control + placebo; G2: control + Eurycoma longifolia; G3: concurrent training + placebo; G4: concurrent training + Eurycoma longifolia). 22 received a 200 mg supplement of Eurycoma longifolia and 23 underwent the intervention with concurrent training, 3 times a week for 60 min at progressive intensity.

Outcomes

International Index of Erectile Function (IIEF-5), Aging Male Scale (AMS) and total testosterone. Results

Erectile function demonstrated improvements in both interventions; however, the most significant results were obtained by men allocated to concurrent training + Eurycoma longifolia.

Clinical implications

A 200 mg supplement of Eurycoma longifolia and the practice of concurrent training for 6 months significantly improved the erectile function of men with ADAM.

Strengths & limitations

The study's design stands out as a strength, in addition to the six-month intervention. The main limitation is the study not having groups that used only Eurycoma longifolia and only concurrent training.

Conclusion

The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.

References:

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Heinemann L.A.J.; Saad F.; Zimmermann T.; Novak A.; Myon E.; Badia X.; et al. (2003) The Aging Males’ Symptoms (AMS) scale: update and compilation of international versions, Health and Quality of Life Outcomes, Volume 1 Pages 1-5, https://doi.org/10.1186/1477-7525-1-15

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